Novel – Key Pax http://key-pax.com/ Sun, 02 Jan 2022 15:31:33 +0000 en-US hourly 1 https://wordpress.org/?v=5.8 https://key-pax.com/wp-content/uploads/2021/05/key-pax-icon-150x150.png Novel – Key Pax http://key-pax.com/ 32 32 Publication in Bengali of the popular Assamese novel “Ashimot Jar Heral Seema” https://key-pax.com/publication-in-bengali-of-the-popular-assamese-novel-ashimot-jar-heral-seema/ Sun, 02 Jan 2022 12:07:00 +0000 https://key-pax.com/publication-in-bengali-of-the-popular-assamese-novel-ashimot-jar-heral-seema/

The launch of two Bengali translation books of famous Assamese novels has made a rich contribution to Assamese and Bengali literature.

This was highlighted in the book release feature of two Bengali translation books ‘Ashime Jaar Haralo Seema’ and ‘1962’ hosted by Dr Anamika Ray Memorial Trust (ARMT) at Assam Book Fair 2021-22 Sunday at Assam Engineering Playground in Guwahati.

The books were translated by Dr Anamika Ray who was an aspiring academician of her time. Although she is from Shantiniketan, West Bengal, she has mastered the Assamese language in no time with intense love and responsibility.

This led her to translate several books of Assamese literature. She has taught at Cotton College, Gauhati University and Central Sikkim University.

On officially releasing the book ‘Ashime Jaar Haralo Seema’, Professor Amalendu Chakrabarty, Founding Vice-Chancellor of Rabindranath Tagore University said: “There is no doubt that the translation of Kanchan Baruah’s famous Assamese novel into Bengali is a rich contribution to Assamese and Bengali readers. .

“It is as important for Bengali readers as it is for fans of Assamese novels. The translation will spark the interest of Assamese and Bengali scholars in further academic research on this great all-time novel, ”he said.

Chakrabarty added that through the publication of this translated book, translator-writer Dr Anamika Ray will live forever among readers and those close to her.

“It is no coincidence that the title of this novel and the short life of the translator have the same meaning of losing limits ad infinitum. Anamika must surpass life to make the presence of her creations on our hands, ”said Chakrabarty.

While Brigadier (Retired) Ranjit Barthakur stressed the importance of translating the history of war, Mrinal Talukdar’s “1962”, as there are few books on the Indochina War of 1962 that have been translated into Assamese.

“We didn’t want to talk about 1962 because we had lost in the war. But at the individual level, there have been many incidents that demonstrated their roles which were courageous and laudable despite the collective loss for failures on many fronts, starting with the political, military or intelligence level, ”Barthakur said. , former president of the Assam civil service. Commission (CSPA).

Barthakur added that translating this war story is another effort to penetrate information – both successful and unsuccessful, and the actual events of the 1962 war among Bengali readers.

The books are published posthumously by the Dr Anamika Ray Memorial Trust (ARMT) on the occasion of the 10e Birthday celebration of the beloved daughter of Dr Ankuran Dutta and the late Dr Anamika Ray Aalphul (Anrini Priyambada).

The Vice-Chancellor of the University of Cotton, Prof. Bhabesh Chandra Goswami, who was the main guest of the program, expressed his appreciation for the translation of Assamese novels, which he says will not only feature great literary works. Assamese people across the country but will also help them understand the war stories from Assam’s point of view.

“It is as important for the younger generation to assimilate into nature as it is to delve deeper into the stories of war,” said Goswami.

Dipak Kumar Baruah, copyright owner of Kanchan Baruah’s “Ashimot Jar Heral Seema”, also attended the program.

In his closing speech, the Vice-President of the Trust, Rajat Baran Mahanta, spoke about the relevance of books in today’s context and the translation of them into various languages, including Bengali, will help to expand this relevance among diverse readers.

“I urge everyone, especially the Bengali public, to come and enjoy these great Assamese literary works of all time as well as another story of the 1962 war,” said Dr Ankuran Dutta, the deputy head of the country. ‘ARMT.

ARMT is a Guwahati-based NITI Ayog registered non-profit educational and charitable organization established in 2015.

The Trust has pioneered the medical anti-terrorism movement in the region, working meticulously for the rights and responsibilities of patients since its inception with a mission mode of recognizing the ‘right to health’ as ​​one of the rights. fundamentals of the Indian Constitution.

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The novelist who saw Central America as it really was https://key-pax.com/the-novelist-who-saw-central-america-as-it-really-was/ Fri, 31 Dec 2021 22:36:38 +0000 https://key-pax.com/the-novelist-who-saw-central-america-as-it-really-was/

Is Babbitt a comic character? A tragic character? Just a running figure of what Lewis’ friend and mentor HL Mencken called “boobish”? The triumph of “Babbitt” is that we cannot confidently answer this question. The name Babbitt entered the language – a “Babbitt” was a ridiculous conformist living in a ridiculously small world. Yet Lewis’s Babbitt is, finally, a man close to our hearts – a character rather than a caricature – one of a small group of American fictional creations that, in the early years of the 20th century, presented themselves to their people. very different ways as landmarks in the history of our country’s social evolution: Sister Carrie of Dreiser, Lily Bart of Wharton, Alice Adams of Booth Tarkington, with Gatsby on the horizon.

Sinclair Lewis was born in 1885. His father was a prominent physician in Sauk Center, a town of about 2,800 people. Read all about it in “Main Street”. Fred, the eldest of the Doctor’s three sons, became a miller and never had much importance in the ambitious Lewis clan. Claude, the next eldest, was of considerable importance: he became a distinguished surgeon, admired and sought after far beyond the town of Saint-Cloud, where he spent his adult life. When Lewis was 62, he admitted that “for 60 years I tried to impress my brother Claude”.

Sinclair Lewis was never really known as “Sinclair”, his middle name. He was Harry, later Hal, ultimately “Red” to everyone who knew him. He was not a physically attractive young man. “He was nearly six feet tall before he was 16,” writes his masterful biographer Mark Schorer, “with a short torso resting on very long, slender legs, and weighed only 120 pounds; lean and thin, but with a puffy, acne-prone face (“pimples” they said), big feet and big hands, poorly coordinated in his movements, everything in his body was hanging and hanging and swaying and rushing and stumbling , and ice-blue eyes (astigmatic) rather protruding, all covered in thatch with a carrot-colored wig.

He also didn’t have the normal happy childhood of the outdoors – skating, swimming, duck hunting – which he claimed to have later; Schorer makes it clear. “He was a queer boy with one true friend in a town full of boys the girls laughed at.” Sports? No. Dances? “Since I can’t dance, I just went with Ma to watch.” But a lot of culture passed through the city: military bands; the Ski-U-Mah Quartet; the Maharas Minstrels; the Schubert Symphony Club; the Casgrove Company playing with musical glasses, bells, mandolins and banjos; and touring theatrical events, from “Uncle Tom’s Cabin” to the Jolly Della Pringle Company.

Most important – crucial – there were books. His father had a modest library and young Harry began to acquire books on his own. (His favorite writers as a boy were Dickens, Scott, and Kipling, and he continued to read them all his life.) For years he was a rotten student, until he graduated high school he started to shine. He was a notorious cutup, imitator and the proud author of “class cries”: “Cooma laca, booma laca, / Bow wow wow – / Chingalaca, chingalaca, / Chow, Chow, Chow”. He had a crush on one girl after another, sometimes two at the same time. He did household chores, he had summer jobs. And he submitted flowery poems to various magazines, all of them, of course, rejected. But he was also preparing for college, having decided to try for Yale, and after spending time at Oberlin honing his skills, he was admitted there.

His career in New Haven has been eventful. His only distinction was being published regularly in Yale Literary Magazine, “The Lit” – romantic stories, more flowery poems. Girls? attempts by the Left. Friends? Some. Privacy? Barely. Prominent educator William Lyon Phelps said of him: “He was not hated in college, but was regarded with kind tolerance as a monster.” His emotional state? As always, loneliness. Yet he was adventurous: one summer he worked as a fattener on a steamboat bound for England; a fall, steerage crossing in Panama, looking for work there.

Then a few years of wandering – a well-known artist community in Carmel, a short stint on a newspaper in San Francisco, the utopian colony of Upton Sinclair in New Jersey. Finally, New York, where he lived in Greenwich Village and found sympathetic companions like Edna Ferber and Frances Perkins, who would become FDR’s famous labor secretary. He made a few dollars selling scraps of stuff to drugged magazines and newspapers, and he sold plots for stories to established writers: Jack London, for one, who in one deal paid him $ 70 for 14 ideas for stories. ‘stories, and Albert Payson Terhune (“Lad: A Dog”) for another. And he had started working on his first novel, “Our Mr. Wrenn”.

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NEWS: Arifureta Zero Spinoff novel ends, main story climaxes – Forum https://key-pax.com/news-arifureta-zero-spinoff-novel-ends-main-story-climaxes-forum/ Thu, 30 Dec 2021 05:48:45 +0000 https://key-pax.com/news-arifureta-zero-spinoff-novel-ends-main-story-climaxes-forum/ See previous topic :: See next topic Author Message TarsTarkas

Registration: 20 Dec. 2007
Messages: 5156
Location: Virginia, United States

To postPosted: Wed Dec 29, 2019 2021 4:35 p.m. Reply with a quote

Quote:

Arifureta – From the mundane to the strongest in the world

I wonder when the next volume in English will be released or is it the last. I’ve been on this cliffhanger for quite a while now.


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Frontier

Joined: Apr 13, 2014
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To postPosted: Wed Dec 29, 2019 2021 4:41 p.m. Reply with a quote

I don’t think the anime is this popular, but I wonder if they’ll ever adapt this spin-off.

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TarsTarkas

Registration: 20 Dec. 2007
Messages: 5156
Location: Virginia, United States

To postPosted: Wed Dec 29, 2019 2021 4:53 pm Reply with a quote

MFrontier wrote:

I don’t think the anime is this popular, but I wonder if they’ll ever adapt this spin-off.

Maybe compared to the best mainstream anime franchises, but it has to have some popularity to get a second season after a dismal first season. That’s why I’m interested.


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tsog

Joined: Sep 16, 2017
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To postPosted: Wed Dec 29, 2019 2021 19:41 Reply with a quote
Back to the top borisdrakoni

Registration: Apr 27, 2019
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To postPosted: Wed Dec 29, 2019 2021 20:11 Reply with a quote

TarsTarkas wrote:
MFrontier wrote:

I don’t think the anime is this popular, but I wonder if they’ll ever adapt this spin-off.

Maybe compared to the best mainstream anime franchises, but it has to have some popularity to get a second season after a dismal first season. That’s why I’m interested.

Although it was widely criticized for the way the story was adapted and the low production values, Arifureta was actually one of the most watched shows of the summer 2019 season, especially in streaming. . In fact, Season 1 is even doing quite well right now in Docomo Anime Store’s weekly streaming rankings, both in terms of views and favorites. Subsequent sales of novels and manga surged by over a million copies thanks to the anime’s release also helped to justify Season 2 of Green Lighting.

Personally, I would be all for an anime adaptation for Zero. They’ve already picked 2 great actors for Oscar and Miledi, and it would be a bit of a waste to use them as sparingly as they did. The (somewhat) darker and more serious tone that (most) lacks the attributes of a typical isekai story might appeal to a larger audience as well.


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BalmungHHQ

Registration: 11 Feb 2006
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To postPosted: Wed Dec 29, 2019 2021 23:24 Reply with a quote


This is probably not the case. It was probably given the green light due to the successful airing of the first season.

It’s not a case like one of those “split-courts in disguise”, for example, especially since the 2nd season was lit over 2 years ago, which means it probably has had to go through the whole pre-production phase from scratch before working. even started.

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LegitCrepe

Registration: June 26, 2017
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To postPosted: Wed Dec 30, 2019 2021 00:43 Reply with a quote

TarsTarkas wrote:

I am wondering when the next volume in English will be released or is it the last. I’ve been on this cliffhanger for quite a while now.

Volume 12, which is indeed considered the last volume of the main series, releases in Japan on January 25, 2022. English translation typically begins around 2-3 months after that, being updated weekly upon membership. from the publisher, then an ebook available in June / July. The pocket release of Seven Seas then probably 4 to 6 months later.

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From Marvel graphic novels to the powerful ‘Razorblade Tears’ crime story, these are the best books of 2021 – YP https://key-pax.com/from-marvel-graphic-novels-to-the-powerful-razorblade-tears-crime-story-these-are-the-best-books-of-2021-yp/ Tue, 28 Dec 2021 09:17:43 +0000 https://key-pax.com/from-marvel-graphic-novels-to-the-powerful-razorblade-tears-crime-story-these-are-the-best-books-of-2021-yp/ With Hong Kong quiet for much of 2021 due to the pandemic, we’ve all had a little extra time to stay home and read. There have been a ton of awesome new releases this year – here are a few of our favorites.

Police are investigating the disappearance of Joy Delaney, a retired tennis teacher. Her 50-year-old husband quickly becomes the prime suspect in the case, and the couple’s four adult children are divided over whether to support their father. Why did she disappear? Is she alive? Does her disappearance have something to do with the mysterious house guest who lived with the family a few months ago, who revealed devastating secrets that turned the lives of the Delaney’s upside down? Moriarty, author of Big little lies and Nine Perfect Strangers – both of which were recently turned into miniseries – weave a fascinating web of mystery that will leave you guessing until the end.

Moriarty’s novel “Big Little Lies” was adapted into a television series starring Shailene Woodley, Reese Witherspoon and Nicole Kidman. Photo: HBO

Razor blade tears by SA Cosby

This powerful detective story is based on the themes of love and acceptance. Two fathers – one black and one white, team up when their gay and married sons are brutally murdered in a horrific hate crime. Together, they embark on a quest for revenge, but first they must confront the prejudices they hold towards each other and towards their recently deceased sons. The characters are portrayed in vivid detail, and the story is full of powerful social commentary. We wouldn’t be surprised to see it made into a movie soon.

The best TV shows of the year

The playlist by Sara Nisha Adams

This heartwarming yet bittersweet story touches on the unifying power of literature and how it can connect and empower people from all walks of life. It tells the story of a widower named Mukesh, who hopes to get in touch with his book-loving granddaughter, Priya. Aleisha, a teenage girl who works at the local library, gives her a list of novels to read, and the books bond these two very different people. With references to various notable literary works, this novel is truly a celebration of fiction.

Christmas pig by JK Rowling

This is JK Rowling’s first children’s book since Harry Potter. It tells the story of a boy named Jack and his beloved childhood toy, Hard Pig (DP). Tragedy strikes when DP is lost, but luckily Jack’s new toy, the boring Christmas Pig, has a daring plan: travel through the land of the lost and save Jack’s best friend. This fantastic novel will transport you to an exciting magical world.

“Christmas Pig” is JK Rowling’s first children’s book since the “Harry Potter” series. Photo: AFP

Tweet Cute by Emma Lord

This book caused a hustle and bustle on BookTok (the book community on TikTok) with its cutesy and light-hearted plot about two regular teenagers, Pepper and Jack, at the center of an internet battle.

Pepper runs the social media accounts for his family’s fast food chain, and when Jack accuses the company of stealing his grandmother’s recipe, sarcastic memes and tweets are exchanged. Their war on Twitter is going viral.

Unbeknownst to them, they also fall in love on an anonymous chat app. This tale about young romance, family expectations and life’s endless surprises is not to be missed.

Fantastic series

The ruin of the empire by Brian Staveley

This book is epic in every sense of the word. The ruin of the empire is the first book in a fantastic new trilogy from Brian Staveley, author of The Blades of the Emperor and the Chronicle of the uncut throne series, and it takes us back to the world of the Annurian Empire in a way you would never expect. It delivers a truly amazing epic story, filled with intricate and unforgettable characters, and even someone who isn’t normally a Staveley fan will be drawn into the dark, spooky, and vivid world he creates.

Spider-Man, Venom, and other great films of 2021

A sky beyond the storm by Sabaa Tahir

The long-awaited final of the An embers in the ashes the series is all you want and more. Following the perspectives of the main characters Laia, Elias Veturius and Helene Aquilla, the book will make you feel love, sorrow, hate and pain all at once. After the shocking revelations revealed in the previous books, one might assume a straightforward exit with a few twists and turns. But again, Tahir manages to surprise everyone and keep readers hooked. The protagonists must determine where their priorities lie while overcoming the losses and living on the brink of war. Will they be able to guess which path fate has chosen for them?

Doctor Who: Dalek by Robert Shearman

Doctor Who fans can finally relive the fan favorite episode “Dalek” through a more detailed and in-depth novel adaptation. The book expands on the episode and gives fans a deep dive into the world it depicts.

Graphic novels

Infinite destinies by Jed Mackay

Mackay brings together some of Marvel’s biggest names, like Iron Man, Captain America, and the Avengers, in a hunt for the Infinity Gems, but with a twist: The gems took the form of people and spread across the universe. Who will exercise their incredible power this time around?

https://twitter.com/Marvel/status/1240344454894170118

Beta Ray Bill: Silver Star by Daniel Warren Johnson

Beta Ray Bill is back with a thunderclap in this new novel, a unique and compelling story from the world of Thor. It’s a dynamic, fun and exciting read for Marvel fans and for those who appreciate creative art styles and graphic novels. It is certainly one of the most compelling Marvel Comics stories in years.

King in Black: Love at first sight by Matthieu Rosenberg

King in Black: Love at first sight is a fun, wacky read that takes place during the dark and depressing King In Black event, when Earth is overrun by symbiotes (aliens taking over a person’s body). The story follows the Thunderbolts, a group made up of Taskmaster, Rhino, Batroc The Leaper, and other killers and soldiers for hire, as they battle through a symbiont-infested New York City.


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What does David Tennant do in this inconsistent, cheap version of such a thrilling novel? https://key-pax.com/what-does-david-tennant-do-in-this-inconsistent-cheap-version-of-such-a-thrilling-novel/ Sun, 26 Dec 2021 18:40:00 +0000 https://key-pax.com/what-does-david-tennant-do-in-this-inconsistent-cheap-version-of-such-a-thrilling-novel/

Around the world in 80 days has one of the great openings of Victorian literature. It’s 1872 and men are sitting around the Reform Club in London, bored and stuffed with bad food. The air is charged with the scent of empire, but we are aware of the possibilities of the great expedition that will follow. In the new version of the BBC, Phileas Fogg (David Tennant) is a still and silent figure. Before deciding to take the £ 20,000 bet to run around the world, he spends most of his time staring at his club mates with a blank expression, as if his mind is very much elsewhere. At the end of the first episode, you wonder if this is just a character breaking Tennant and what he does in this rather inconsistent and cheap version of such a thrilling novel.

Yet during the first few minutes of the Victorian gloom, it appears to be a straightforward narrative, a rare event in today’s television world of almost “reinvention” and “re-imagining”. mandatory. The illusion does not last long: although it takes place in the 19th century, it tends towards contemporary relevance. Fogg’s valet, Passepartout, is a black man, played by a Franco-Malian actor, Ibrahim Koma. This Passepartout is not a gentleman’s gentleman, but a chancellor, a man who worked as a waiter in the club before being fired for fighting and hearing Fogg calling someone to help him. The third member of the traveling group, Fix, a detective in the book, is here transformed into a female Abigail “Fix” Fortescue (Leonie Benesch), and a hack to boot, a fiery Telegraph journalist responsible for covering Fogg’s mission.

Their cohort of the 21st century gathered, they set off on an adventure. In Verne’s novel, they head straight for Suez, but here they turn away across Europe, more like scattered interrails from a gap year than explorers of the world. Their first stop is Paris, where Passepartout turns out to have unfinished business with a brother and a little light revolution. The rest of the episode quickly descends into a sort of chaotic mishmash of Wretched and Jackal’s Day, all assassinations and uprisings. The idea is to introduce a subplot about racism and social justice, but the long action sequences come at the expense of any meaningful character development, especially among the protagonists. At eight episodes, this series depends on the relationship between them. The actors do what they can with limited time and dialogue, and Tennant is still good for his money, but he’s a bit of a steer.

The biggest problem is that the reach and budget of modern television has exceeded this type of production. If you take a property as famous as Around the world in 80 days and put it on BBC One at Christmas, you gotta give it some welly. The public is alerted to the tricks you may have gotten away with before. London and Paris look almost identical here, perhaps both shot on the same block in Romania. In each frame you can feel the cut corners. A scene of mass revolution is conveyed by a fixed shot of Paris and sound. The joy of the source text for readers was that it was truly exotic, spanning from Egypt to India, China, Japan, and across the United States. When you watch a series like ZeroZeroZero, shot outdoors in Italy, Mexico, Senegal, the United States and Morocco, the authenticity is obvious. Television is finally able to faithfully remake Around the world in 80 days, so why not give it the treatment it deserves?

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What Writing My Novel Taught Me About Being a Lawyer | Rachel Goldenberg https://key-pax.com/what-writing-my-novel-taught-me-about-being-a-lawyer-rachel-goldenberg/ Fri, 24 Dec 2021 15:17:00 +0000 https://key-pax.com/what-writing-my-novel-taught-me-about-being-a-lawyer-rachel-goldenberg/ Rachel Goldenberg It all started after I wrote an article for The Lawyer Daily. I had already written a few legal articles for publication, providing commentary on interesting case law and current developments. But one day my editor asked me for …]]>
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Rachel Goldenberg

It all started after I wrote an article for The Lawyer Daily. I had already written a few legal articles for publication, providing commentary on interesting case law and current developments. But one day my editor asked me for a more personal article, reflecting on the impact of COVID-19 on me and my professional trajectory. At first I was worried that I wouldn’t be able to find the words, but it was a pleasant surprise how easily the words came out of me.

From there, I preferred to write opinion pieces. Share pieces of myself with others, while gaining confidence in my writing style. It occurred to me – maybe I’m a good writer? At least one writer that’s decent enough that some people might enjoy reading my work?

Strong positive feedback for my articles in The Lawyer Daily, I decided to take the plunge and pursue my lifelong dream of writing a novel. And guess what? I did it! Free plug: Discover A deadly truth by Rachel Goldenberg for some fun holiday read! The link is below in my author bio.) Inspired by John Grisham, Scott Turow, William Landay and so many other lawyers turned writers, I wrote a psychological thriller with a lawyer as the protagonist. As they say, write down what you know.

Writing a novel has been an incredible, terrifying therapeutic experience. It was so different from anything I had written before. I started my legal career by drafting pleadings, affidavits and do. How to write about characters who do not exist? How do I breathe life into ideas that I had only imagined until now?

I started with the basics. I started with what I learned as a lawyer. Just like an affidavit, tell the facts. Determine the story you want to tell and, in consecutive order, state each fact. And that’s exactly what I did, laying out a 10 page factual overview to tell my story.

But 10 pages of facts is not very interesting. It’s useful for a motion, setting out the evidence needed to prove your position, but it’s flat. I switched to my persuasive writing skills. Just like an oral argument, you set the stage for the facts and you describe the big picture. Much like a factum, you put a twist on your position to persuade the reader to believe your story.

Finally, I had to tackle the last layer of the story, the most delicate: adding emotions. You want your reader to not only believe in your story, but to feel it. Meet these characters and invest in them. To identify with them. Grounding for the protagonist (or antagonist, no judgment here). This was the hardest part for me because it was so different from all of my previous legal writing experiences.

It went against all my training as a lawyer. Image writing an affidavit in support of a motion that includes descriptive backgrounds and emotional ideas. Imagine what the cross-examinations on these affidavits would look like! But as lawyers, do we go too far and sometimes forget about emotions? While this might just be another issue for us, for our clients, it’s their life. The stakes are high. The process, and even the result, can be traumatic. It can be easy to forget as a lawyer.

So what did I learn about the legal profession from writing a book? I have learned that being a lawyer has taught me invaluable writing skills. It taught me to write effectively and convincingly. But I also learned that being a lawyer has the potential to crush my emotional side. That sometimes we need to activate our sympathy and empathy when dealing with customers. I also learned that deep within me was an artistic and imaginative storyteller waiting to be released.

And I released her. I wrote a book. How cool is that? For all the other lawyers who have a secret aspiration to write a detective novel, I urge you to do so. Try something new. Push your limits. What’s the worst that can happen? You crash and burn and no one reads your book?

Oh no. I hope I don’t crash and burn. Please read my book!

Rachel Goldenberg is Executive Property Manager at Adams & Waks Construction and author of A deadly truth.

Interested in writing for us? Find out more about how you can add your voice to The Lawyer Daily, contact analysis editor Peter Carter at peter.carter@lexisnexis.ca or call 647-776-6740.

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Adagene achieves key milestone in collaboration with Exelixis for new SAFEbody® masked antibody-drug conjugate candidates https://key-pax.com/adagene-achieves-key-milestone-in-collaboration-with-exelixis-for-new-safebody-masked-antibody-drug-conjugate-candidates/ Wed, 22 Dec 2021 21:05:00 +0000 https://key-pax.com/adagene-achieves-key-milestone-in-collaboration-with-exelixis-for-new-safebody-masked-antibody-drug-conjugate-candidates/

– Successful nomination of key SAFEbody candidates triggers milestone payment –

SAN DIEGO and SUZHOU, China, December 22, 2021 (GLOBE NEWSWIRE) – Adagene Inc. (“Adagene”) (NASDAQ: ADAG), a biopharmaceutical company committed to transforming the discovery and development of novel antibody-based immunotherapies, today announced the achievement of a key milestone in its ongoing collaboration with Exelixis for the development of novel masked antibody-drug conjugate (ADC) candidates leveraging Adagene’s proprietary SAFEbody precision masking technology. Under a collaboration and license agreement established in early 2021, Adagene will receive a milestone payment of $ 3 million for the successful nomination of SAFEbody top candidates for one of its collaboration programs.

“We are extremely proud to have successfully delivered SAFEbody lead candidates to Exelixis after starting our collaboration earlier this year. Exelixis’ selection of these prime candidates further validates our proprietary SAFEbody technology and highlights the prowess of our global DPL platform, ”said Peter Luo, Ph.D., Co-Founder, CEO and President of ‘Adagene. “Our SAFEbody masking technology receives clinical validation in our ongoing clinical trial of our anti-CTLA-4 monoclonal antibody program, and also marks a potential paradigm shift in how a very potent modality such as ADCs can. be designed and developed, ultimately helping to improve the lives of patients with cancer and other debilitating diseases. “

Under the terms of the agreement, Adagene has received an upfront payment of $ 11 million and Exelixis may designate two targets for SAFEbody candidate development during the collaboration. Adagene is eligible for development and commercialization milestones, as well as royalties on net sales of products developed around each of these targets.

SAFEbody technology is designed to overcome the safety and tolerability challenges associated with many antibody treatments by using precision masking technology to protect the binding domain of biologic therapy. This helps improve targeting of tumor-specific antibodies, while minimizing off-target toxicity on the target in healthy tissue, a long-standing challenge with many antibody-based treatments.

In addition to ongoing collaborations, Adagene is also applying its SAFEbody technology to develop candidates for its deep, broad and differentiated wholly owned pipeline. These include ADG126, a phase 1 dose escalation anti-CTLA-4 SAFEbody as monotherapy, as well as five highly differentiated programs in IND studies such as ADG153, an anti-CTLA-4 SAFEbody. -CD47 using the powerful IgG1 isotype -Bispecific POWERbody ™ T-cell receptor CD20xCD3. A total of five antibodies are under clinical development by Adagene and its partners, leveraging the company’s AI-powered antibody discovery and development platform.

About Adagene
Adagene Inc. (NASDAQ: ADAG) is a platform-driven, clinical-stage biopharmaceutical company committed to transforming the discovery and development of novel antibody-based cancer immunotherapies. Adagene combines computational biology and artificial intelligence to design new antibodies that meet unmet patient needs. Powered by its proprietary Dynamic Precision Library (DPL) platform, comprised of NEObody ™, SAFEbody® and POWERbody ™ technologies, Adagene’s highly differentiated pipeline includes new immunotherapy programs. Adagene has forged strategic collaborations with reputable global partners who leverage its technology in multiple approaches at the forefront of science.

For more information, please visit: https://investor.adagene.com.

SAFEbody® is a registered trademark in the United States, China, Australia, Japan, Singapore, and the European Union.

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This press release contains forward-looking statements, including statements regarding the potential implications of the clinical data for patients, and Adagene’s anticipated clinical progress and activities, clinical development, regulatory milestones and the commercialization of its product candidates. . Actual results may differ materially from those shown in forward-looking statements due to various important factors including, but not limited to, Adagene’s ability to demonstrate the safety and efficacy of its drug candidates; the clinical results of its drug candidates, which may not support further development or regulatory approval; the content and timing of decisions made by relevant regulatory authorities regarding the regulatory approval of Adagene drug candidates; Adagene’s ability to achieve commercial success for its drug candidates, if approved; Adagene’s ability to obtain and maintain intellectual property protection for its technology and drugs; Adagene’s dependence on third parties to carry out drug development, manufacturing and other services; Adagene’s limited operating history and Adagene’s ability to obtain additional financing for its operations and to complete the development and commercialization of its drug candidates; Adagene’s ability to enter into additional collaborative arrangements beyond its existing strategic partnerships or collaborations, and the impact of the COVID-19 pandemic on Adagene’s clinical development, business and other operations, as well as the risks more fully discussed in the “Risk Factors” section in the documents filed by Adagene with the United States Securities and Exchange Commission. All forward-looking statements are based on information currently available to Adagene, and Adagene makes no commitment to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise, unless required by law. .

Internal contact:
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Adagene
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ir@adagene.com

External contact:
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LifeSci Advisors
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Design of a new propulsion system for an unmanned biomimetic underwater vehicle https://key-pax.com/design-of-a-new-propulsion-system-for-an-unmanned-biomimetic-underwater-vehicle/ Tue, 21 Dec 2021 09:07:40 +0000 https://key-pax.com/design-of-a-new-propulsion-system-for-an-unmanned-biomimetic-underwater-vehicle/

A team of researchers in Poland has developed a new energy-saving propulsion system design for an unmanned biomimetic underwater vehicle (BUUV). Published in the journal Energies, the team details its research on the innovative design of the propulsion system.

To study: Innovative energy-saving propulsion system for low-speed biomimetic underwater vehicles. Image Credit: Humberto Ramirez / Shutterstock.com

Designers and engineers have long admired the forms of nature and its ability to adopt new ways of solving problems and to integrate seamlessly into the environment. Nature has a seemingly endless capacity to produce systems that are both innovative and efficient.

By developing new technological systems, designers and engineers have adapted to the concept of biomimicry which produces innovative and high performing models, tools and structures based on those of the natural world.

A BUUV (a) with the following movement phases: (b – d) power stroke and (e – g) return stroke;  1 — additional articulation.

A BUUV (a) with the following movement phases: (b – d) power stroke and (for example) return run; 1 — additional articulation. Image credit: Piskur, P et al., Energies

UUV to BUUV

Unmanned Underwater Vehicles (UUVs), also known as underwater drones, are submersible vehicles that can navigate their way through various water systems with or without human intervention. Generally, UUVs fall into two categories, remotely operated underwater vehicles or autonomous underwater vehicles.

Traditional submarine propulsion systems, such as screw-type axial propellers, convert torque into thrust; in other words, the power of an engine turns the propellers and generates force by moving the flow of water down and behind the blade.

However, biomimetic systems that turn UUVs into UUVs are attracting a lot of attention as they demonstrate higher propulsion efficiency, improved maneuverability, and quieter actuation than conventional UUVs equipped with axial propellers.

Biomimetic systems can be designed to move like a fish, turtle, seal, or other marine life that ripples to generate propulsion by pushing water against passing waves. However, the impact of tail oscillation on the flow of fluid around a shell can result in vortices and therefore requires the study of FSI and vortex structures.

In addition, existing BUUV designs often feature many moving parts that combine rigid and flexible shapes, resulting in a complex structure not without flaws: “This type of construction is difficult to control, expensive and increases the risk of flooding the electronic components inside”, explains Dr Paweł Piskur of the Faculty of Mechanical and Electrical Engineering, Polish Naval Academy, Gdynia, Poland.

Two types of propulsion systems used for the tests: flexible aileron during movement counterclockwise (a) and clockwise (b);  the beater with an additional joint during the power stroke (c) and return (d).

Two types of propulsion systems used for testing: flex fin during counterclockwise direction (a) and clockwise (b) movement; the pinball machine with an additional seal during power (vs) and back (D) stroke. Image credit: Piskur, P et al., Energies

Innovative propulsion systems

New biomimetic propulsion systems the researchers designed incorporate two fins mounted on a drive mechanism with fewer moving parts and components than existing models. “The movement of the two fins outward is simply an auxiliary movement which achieves the specified values ​​of the maximum angular deviation of the fins from the longitudinal axis of symmetry, which is necessary to start the working movement , Piskur said.

The fins work by pushing the fins inward and pushing the water outward in opposition to the body of the BUUV, then return to the starting position with a reduction in force generated by a position shift: “During the movement, the ailerons change position from the vertical plane to the horizontal plane. This reduces the hydrodynamic drag of the ailerons during outward movements and, consequently, the drag of underwater vehicles ”, explains Piskur.

The goal of this system is to address some of the challenges associated with current biomimetic models by reducing the number of design and control variables to demonstrate the difference between an innovative propulsion system and a wave system.

“Increasing the speed of the fins during the generation of thrust while decreasing the speed of the fins during the return movement should result in even better efficiency” Piskur said.

The propulsion system has demonstrated higher thrust capabilities and improved net efficiency for low speed movements, thus ensuring the biomimetic nature of the movement. The team says further testing will be done to assess a body’s impact on the new propulsion system design, as well as to incorporate additional articulation and flexible fins to accommodate different styles of movement.

The laboratory water tunnel: 1 — Dynamixel MX-12W servomechanical, 2 — strain gauges, 3 — ball bearings, 4 — microcontroller unit (MCU) and strain gauge amplifier, 5 — ultrasonic flow sensors , 6 — ultrasonic flow unit, 7 — hydraulic flywheels, 8 — external water pump, 9 — power supply, and 10 — aileron.

The laboratory water tunnel: 1 — Dynamixel MX-12W servomechanical, 2 — strain gauges, 3 — ball bearings, 4 — microcontroller unit (MCU) and strain gauge amplifier, 5 — ultrasonic flow sensors , 6 — ultrasonic flow unit, 7 — hydraulic flywheels, 8 — external water pump, 9 — power supply, and 10 — aileron. Image credit: Piskur, P et al., Energies

The team hopes that the promising results of this study will be transferred to newer and improved models based on the same system and, as such, will help to create BUUVs that accurately mimic the movements and high energy efficiency of organisms. living sailors. The team has filed a patent for their design which is currently in progress.

Advanced robotics, including UUVs and BUUVs, opens up an ocean of possibilities for exploring underwater environments that can aid in ocean monitoring, seabed mapping, pipeline inspections and more.

The references

Piskur, P .; Szymak, P .; Przybylski, M .; Naus, K .; Jaskolski, K .; Żokowski, M. Innovative energy-saving propulsion system for low-speed biomimetic underwater vehicles. Energies 2021, 14, 8418. https://www.mdpi.com/1996-1073/14/24/8418

Disclaimer: The views expressed herein are those of the author, expressed in a private capacity and do not necessarily represent the views of AZoM.com Limited T / A AZoNetwork, the owner and operator of this website. This disclaimer is part of the terms and conditions of use of this website.

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Deb Aronson | A novel to help young readers overcome grief | Books https://key-pax.com/deb-aronson-a-novel-to-help-young-readers-overcome-grief-books/ Sun, 19 Dec 2021 15:30:00 +0000 https://key-pax.com/deb-aronson-a-novel-to-help-young-readers-overcome-grief-books/

One of the reasons I found Joanne Levy’s ‘Sorry for Your Loss’ such a compelling read is that it speaks candidly about the loss and grief it feels when someone we love dies. .

This is the first mid-level book I’ve read that talks so explicitly about things like how grieving is different for different people and at different times, and what the job of a funeral director, or the funeral director, is. A friend’s job (for that matter), is not to resolve someone’s grief, but only to support people as they go through it.

The main character, Evie Walman, lives with her parents and brother.

The family operates a funeral home.

It makes death more central to family life than if the family had a different business, and it also gives Levy the opportunity to demystify the grieving process, including funerals and other gatherings.

Evie is currently helping out at the funeral home by vacuuming, restocking water bottles and handing out tissues.

She sees that what her parents are doing, comforting people and supporting them in their grief, is a truly important service to their community.

She thinks she wants to be an undertaker when she’s older.

Sadly, some kids in Evie’s small private school don’t see what Evie’s family does as a positive calling.

They use her as an excuse to intimidate Evie, calling her a “zombie” and claiming that she smells like a rotting corpse.

She hates being bullied, but Evie doesn’t have any friends, and she usually doesn’t mind.

She made a friend at summer camp, where she learned to pluck.

This friendship ended badly in a way that marked Evie so much that she says she doesn’t want to have another friend. Never.

So when Oren comes into her life, through the funeral home (her parents were killed in a car crash, he survived and now lives with his uncle), she is ready to help under the guise of junior funeral director. , but she is firm that she does not need a friend.

As Oren hasn’t spoken since the accident, it’s working out well for both of them.

But slowly, slowly, things are changing.

Evie considers it a personal challenge to get Oren to speak, and when she gets the hint of a smile, she feels the thrill of success.

But Oren is, of course, devastated, and Evie learns to hold back her persistence and positive attitude, to follow Oren’s example instead of grabbing him by the nose.

It’s a great learning experience to support Evie.

It at least helps the story that Oren communicates via text!

Evie’s hobby, quilling, serves as a connection point.

I let the reader find out how quilling connects them.

But also, look for quilling!

The videos make it look easy, but it’s probably a question of how good you are with your hands. The end results are amazing!

Meanwhile, the story does a great job of modeling how to help someone grieve.

Evie and Oren develop a shorthand for DYNAH, which means “do you need a hug?” The message here is, again, to follow the other person’s lead and ask them to give them a hug, rather than just doing it (in case the person isn’t comfortable with receive a hug at that time).

Because Walman Memorial Chapel is a Jewish funeral home, we learn many traditions specific to Judaism, including that funerals take place just a day or two after death, there is no cremation or embalming, although the body is carefully, lovingly and ritually washed. There is also the practice of the seated shiva, a week-long period of mourning during which friends and family come to visit and pray with the immediate family of the deceased.

Levy also introduces readers to the tradition of leaving a pebble on the gravestone when visiting the cemetery.

While some practices may be specific to Judaism, the spelling of stages of mourning helps demystify death and the traditions around death for all readers.

Perhaps this will make a reader interested in the traditions of their own culture and want to know more about them.

Now more than ever, we need these kinds of books for readers of all ages.

From quilling to DYNAH and seated shiva, “Sorry for Your Loss” fulfills a great need for the mid-level canon.

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Video: Davidow talks to Manchester about his latest novel and Jewish history https://key-pax.com/video-davidow-talks-to-manchester-about-his-latest-novel-and-jewish-history/ Fri, 17 Dec 2021 22:42:28 +0000 https://key-pax.com/video-davidow-talks-to-manchester-about-his-latest-novel-and-jewish-history/

Author and lawyer Michael Davidow is pictured speaking at Temple Israel in Manchester. BEVERLY STODDART Video

By BEVERLY STODDART, The Life of an NH Writer

Michael Davidow, known for his series of books, The Henry Bell Trilogy, gave us a new book, The hunter of Talyashevka and spoke about it Wednesday night at Temple Israel Synagogue in Manchester.

The novel is set in 1926 in Kiev, the Ukrainian capital. The novel is described as “a thoughtful journey through the mythology and beauty of the Jewish past. The religious themes at the heart of its history are central to our lives, even today.

Davidow, a lawyer and author who lives in Bedford, brings us a beautifully written novel that enlightens and educates us with a complex and well-researched plot.

Davidow also writes the “Radio Free New Hampshire” column for InDepthNH.org. You can read them here: http://indepthnh.org/series/radio/

He is the author of Gate City, Split Thirty and The Rocketdyne Commission, three novels about politics and advertising that together form The Henry Bell Project, The Order Book, and his most recent, The Hunter of Talyashevka. They are available on Amazon and Barnes and Noble.

Beverly Stoddart’s column “A NH Writer’s Life” can also be found on InDepthNH.org here: http://indepthnh.org/series/beverly-stoddart/

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